E.K Herb Factory Supply Wholesale Camptothecin 98% Camptotheca Acuminata Extract
Camptothecin (CPT) is a cytotoxic quino line alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.
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Product Name
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Camptotheca Acuminata Extract |
| Botanical Source |
Camptotheca Acuminata Decne |
|
Used Part
|
Nut |
|
Specification
|
98% Camptothecin
|
|
Appearance
|
Light yellow crystalline powder
|
|
CAS NO.
|
7689-03-4 |
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Test Method
|
HPLC
|
|
Extraction type
|
Solvent Extraction
|
|
Molecular Formula
|
C20H16N2O4 |
|
Molecular Weight
|
348.36
|
| Grade |
Pharmaceutical and food grade |
|
Shelf life
|
2 years
|
Camptothecin is a quinoline-based alkaloid found in the barks of the chinese camptotheca tree and the Asian nothapodytes tree.
Camptotheca acuminate as the fruit and root of the Chinese dove tree with cold nature and bitter flavor.
Functions :
1. Anti tumor effect.
2. Camptothecin can inhibit the proliferation of fibroblasts both in vivo and in vitro.
3. In addition, camptothecin has obvious inhibitory effect on herpesvirus.
4. In vivo, camptothecin is mainly excreted from bile and urine.
5. Camptothecin can induce chromosome aberration and is toxic.
6. Treatment of esophageal cancer, cardiac cancer.
7. Treatment of gastric cancer.
8. Treatment of primary liver cancer.
9. Treatment of psoriasis.
10. Treatment of skin warts.
Applications:
1. Applied in the functional food field;
2. Applied in the health product field;
3. Applied in the pharmaceutical field.
Certificate of Analysis:
| Physical Control |
| Appearance |
Crystalline Powder |
Complies |
Visual |
| Color |
Light Yellow |
Complies |
Visual |
| Odor |
Characteristic |
Complies |
Organoleptic |
| Taste |
Characteristic |
Complies |
Organoleptic |
| Particle Size 100 |
100% pass 80 mesh |
Complies |
80 Mesh Screen |
| Loss on Drying |
5% Max |
3.41% |
CPh |
| Ash |
5%Max |
3.33% |
CPh |
| Part of Plant Used |
Leaf |
Complies |
/ |
| Solvent Extract |
Water |
Complies |
/ |
| Excipient |
5%-10% Maltodextrin |
Complies |
/ |
| Chemical Control |
| Heavy metals |
NMT10ppm |
Conforms |
Atomic Absorption |
| Arsenic (As) |
NMT 2ppm |
Conforms |
Atomic Absorption |
| Mercury(Hg) |
NMT 1ppm |
Conforms |
Atomic Absorption |
| Lead (Pb) |
NMT 2ppm |
Conforms |
Atomic Absorption |
| GMO Status |
GMO Free |
Conforms |
/ |
| Solvent Residual |
Meet E.P Standard |
Conforms |
Ph.Eur |
| Pesticides Residues |
Meet USP Standard |
Conforms |
Gas Chromatography |
| Benzo(a)pyrene |
NMT 10ppb |
Conforms |
GC-MS |
| Sum of benzo(a)pyrene, benz(a)anthracene, benzo(b)fluoranthene and chrysene |
NMT 50ppb |
Conforms |
GC-MS |
| Microbiological Control |
| Total Plate Count |
10000cfu/g Max |
Conforms |
AOAC |
| Yeast & Mold |
300cfu/g Max |
Conforms |
AOAC |
| S. aureus |
Negative |
Negative |
AOAC |
| E.Coli |
Negative |
Negative |
AOAC |
| Salmonella |
Negative |
Negative |
AOAC |
| Pseudomonas aeruginosa |
Negative |
Negative |
USP |
Hunan E.K Herb Co.,Ltd. founded in 2010, is a modern high-tech enterprise committed to plant functionality, the extraction and purification of active ingredients.Based on the construction of a high starting point, the company has the domestic leading plant extract production line, is a refined production workshop with nearly 3000 square meters and nearly 20 mu of standardized crude lifting production workshop of large-scale production enterprises, its core technology in the leading position in the domestic peers.E.K Herb with advanced production equipment and high-tech research and development level, characterized by high quality product quality, on the basis of integrity service consciousness and high level of service attitude, constantly launch new products, improve the enterprise platform, improve the corporate image, serve the society, just to create greater social value and economic benefits.
E.K Herb mainly features high purity products,such as Chlorogenic acid 98%, Ursolic acid 98%,Rosmarinic acid 98%,Carnosic acid 95% ,Amygdalin 98%, Dihydromyricetin 98%, Resveratrol 98%, EGCG 95%,, and personalized product demand, we use technical advantages, and strong research and development ability, to provide product customization and research and development outsourcing services, to meet the needs of different customers.The scope of products covers chemical industry, medicine, food, cosmetics and other fields, in the past ten years, E.K Herb has always uphold the spirit of ingenuity, to ensure the quality, with first-class quality second-rate prices, specifications, fast and thoughtful service by the majority of users.And applied for the five invention patents of "high purity green raw acid preparation process" ,"high purity lycopene preparation process", "High purity Rosemary acid preparation process", "High purity Ursolic acid preparation process", "High purity Amygdalin preparation process",and successfully passed the QS, 1S09001 and other certification.
ABOUT US
E.K Herb insists in the principle of Top Quality, Excellent Service, Outstanding R&D innovation, Best After-sale Services.
E.K Herb adheres to the spirit of excellence and continuous innovation, strives for the develop and booms of the plant extract industry!
To be your faithful and reliable partner!
E.K Office, R&D
E.K Factory
Our Exhibition
E.K Culture --- Team Building
Customer's Feedback
Packing & Shipping
Packing
* Delivery Time: Around 3-5 workdays after your payment.
* Package: In fiber-drums with two plastic bags inside.
* Net Weight: 25kgs/drum,Gross Weight: 28kgs/Drum
* Drum Size & Volume: I.D.42cm × H52cm, 0.08 m³/ Drum
* Storage: Stored in dry and cool place, keep away from strong light and heat.
* Shelf Life: Two years when properly stored.
shipping
* DHL Express, FEDEX and EMS for quantity less than 50KG, usually called as DDU service.
* Sea shipping for quantity over 300KG; and air shipping is available for 50KG above.
* For high value products, please select air shipping and DHL express for safe.
* Please confirm if you can make the clearance when goods reach your customs before placing an order. For buyers from Mexico, Turkey, Italy, Romania, Russia, and other remote area.
FAQ
Q1: What's the difference between herb extract and powder?
A: The extract is a concentrated powder form of raw material. The herb extract's procedure flow is wash, extraction, concentration, purification, drying, grinding, sieving, package. The herb powder is just a powder form of the herb. The procedure flow is wash, drying, grinding, sieving, package.
Q2: What's the extract solvent used in the procedure?
A: The extract solvent is always depending on the active ingredient in the raw material, regulation and customers' requirement. The solvents mostly used for extraction are water and ethanol. Even the solvent other than water used in the procedure, the solvent residue in the extract product also can conform with ICH Q3CR5.
Q3: Is there any other ingredient used in the product?
A: It depends. For product which is hard to be dried, we need to add some maltodextrin into the extraction solution before drying. The maltodextrin we used is food-class carrier, from non-GMO corn. We can share customer with the ingredient composition table.
Q4: How to make sure the quality of the product?
A: Firstly, every batch finish product must be tested and qualified before delivery. We can send a specification sheet or CoA for confirmation. The HPLC chromatography graph also can be provided. Secondly, we can provide pre-ship sample to customer for quality confirmation.
Q5: Can you develop a new product for us?
A: Yes, we can. We have independent R&D dept, who is able to update the procedure parameters of our main products and develop the procedure of new product. For more information, please contact us directly.
Q6: Can you offer this in capsules or tablets as well?
A: Yes, we have related equipment for preparation of finish product, like tablet, capsule and granule. Kindly contact with us for details.
Q7: What is the MOQ?
A: For most of the products we already have in stock, the MOQ is 1kg. If the product is a new specification and need to be produced from raw material, the MOQ depends.
Q8: Is there any discount?
A: Yes, for larger quantity or better payment period, we can support with better price.
Q9: How about delivery time?
A: For most products, the product can be sent out from factory in 5days. If we don't have inventory, the product need to produced from raw material, the ordinary period is 20-25days.
Q10: How do you treat with quality complaint?
A: We will always be responsible for the quality of our products. If there's a complaint, we will first assist customers to solve the most direct needs.
Secondly, we have SOP for quality complaint. QA will investigate the problem, after that we'll give customer a formal feedback about the cause of the quality issue and related precautions for this problem.
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