Customization: | Available |
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Certification: | ISO, HACCP, Halal, Kosher |
Assay Method: | HPLC, UV |
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Camptothecin (CPT) is a cytotoxic quino line alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.
Product Name
|
Camptotheca Acuminata Extract |
Botanical Source | Camptotheca Acuminata Decne |
Used Part
|
Nut |
Specification
|
98% Camptothecin
|
Appearance
|
Light yellow crystalline powder
|
CAS NO.
|
7689-03-4 |
Test Method
|
HPLC
|
Extraction type
|
Solvent Extraction
|
Molecular Formula
|
C20H16N2O4 |
Molecular Weight
|
348.36
|
Grade | Pharmaceutical and food grade |
Shelf life
|
2 years
|
Functions :
1. Anti tumor effect.
2. Camptothecin can inhibit the proliferation of fibroblasts both in vivo and in vitro.
3. In addition, camptothecin has obvious inhibitory effect on herpesvirus.
4. In vivo, camptothecin is mainly excreted from bile and urine.
5. Camptothecin can induce chromosome aberration and is toxic.
6. Treatment of esophageal cancer, cardiac cancer.
7. Treatment of gastric cancer.
8. Treatment of primary liver cancer.
9. Treatment of psoriasis.
10. Treatment of skin warts.
1. Applied in the functional food field;
Physical Control | |||
Appearance | Crystalline Powder | Complies | Visual |
Color | Light Yellow | Complies | Visual |
Odor | Characteristic | Complies | Organoleptic |
Taste | Characteristic | Complies | Organoleptic |
Particle Size 100 | 100% pass 80 mesh | Complies | 80 Mesh Screen |
Loss on Drying | 5% Max | 3.21% | CPh |
Ash | 5%Max | 3.13% | CPh |
Part of Plant Used | Nut | Complies | / |
Solvent Extract | Water | Complies | / |
Excipient | 5%-10% Maltodextrin | Complies | / |
Chemical Control | |||
Heavy metals | NMT10ppm | Conforms | Atomic Absorption |
Arsenic (As) | NMT 2ppm | Conforms | Atomic Absorption |
Mercury(Hg) | NMT 1ppm | Conforms | Atomic Absorption |
Lead (Pb) | NMT 2ppm | Conforms | Atomic Absorption |
GMO Status | GMO Free | Conforms | / |
Solvent Residual | Meet E.P Standard | Conforms | Ph.Eur |
Pesticides Residues | Meet USP Standard | Conforms | Gas Chromatography |
Benzo(a)pyrene | NMT 10ppb | Conforms | GC-MS |
Sum of benzo(a)pyrene, benz(a)anthracene, benzo(b)fluoranthene and chrysene | NMT 50ppb | Conforms | GC-MS |
Microbiological Control | |||
Total Plate Count | 10000cfu/g Max | Conforms | AOAC |
Yeast & Mold | 300cfu/g Max | Conforms | AOAC |
S. aureus | Negative | Negative | AOAC |
E.Coli | Negative | Negative | AOAC |
Salmonella | Negative | Negative | AOAC |
Pseudomonas aeruginosa | Negative | Negative | USP |
Q1: Can i get some samples? |
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers. |
Q2: How to start orders or make payments? |
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union |
or Paypal or Escrow(Alibaba). |
Q3: How to confirm the Product Quality before placing orders? |
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the |
samples. You can send us your product specifications and requests,we will manufacture the products according to your requests. |
Q4:What's your MOQ? |
A:Our MOQ is 1kg or 10g(Different products have different MOQs). But usually we accept less quantity such as 10g on the condition that sample charge is 100% paid. |
Q5: How about delivery leadtime? |
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included) |
Q6:Is there a discount? |
A:Different quantity has different discount. |
Q7: How do you treat quality complaint? |
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, |
we will send you free goods for replacement or refund your loss. |
Q8: How to contact us ? |
A:You can chat with us by Trademanager Online. You can choose your interested products and send inquiry to us. |